Croatica Chemica Acta, Vol. 97 No. 2, 2024.
Izvorni znanstveni članak
https://doi.org/10.5562/cca4097
Investigation of Mechanochemical Thianthrene-Mediated Aryl C−H Functionalization
Leonarda Vugrin
; Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia
Ivica Cvrtila
; Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia
Hervé Geneste
; AbbVie Deutschland GmbH & Co. KG, Global Medicinal Chemistry - SMTPT, Ludwigshafen D-67061, Germany
*
Ivan Halasz
; Ruđer Bošković Institute, Bijenička c. 54, 10000 Zagreb, Croatia
*
* Dopisni autor.
Prilozi: cca4097_supplement.pdf
Sažetak
We report an efficient solvent-free approach for palladium-catalyzed coupling reactions exploiting S-aryl-thianthrenium salts as intermediates. All reaction steps – thianthrene oxidation, arene thianthrenation, and thianthrenium salt functionalization – can be achieved with high yields mechanochemically, without the need for inert conditions, thus offering significant savings in time, energy, and organic solvents.
Ključne riječi
thianthrene; arene C-H functionalization; mechanochemistry; solid-state synthesis; ball milling
Hrčak ID:
319890
URI
Datum izdavanja:
27.7.2024.
Posjeta: 509 *