Izvorni znanstveni članak

https://doi.org/10.20471/acc.2024.63.01.16

The impact of preoperative salivary urea and superoxide dismutase activities on postoperative pain after surgical removal of mandibular third molars

Nino Grgić ; Department of Oral and Maxillofacial Surgery, School of Dental Medicine, University of Zagreb, Dubrava University Hospital, Zagreb, Croatia
Marko Tarle ; Department of Oral and Maxillofacial Surgery, School of Dental Medicine, University of Zagreb, Dubrava University Hospital, Zagreb, Croatia
Ante Perić ; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Slavica Potočki ; Department of Medical Chemistry, Biochemistry and Clinical Chemistry, School of Medicine, University of Zagreb, Zagreb, Croatia
Daria Pašalić ; Department of Medical Chemistry, Biochemistry and Clinical Chemistry, School of Medicine, University of Zagreb, Zagreb, Croatia *
Berislav Perić ; Department of Oral and Maxillofacial Surgery, School of Dental Medicine, University of Zagreb, Dubrava University Hospital, Zagreb, Croatia

* Dopisni autor.

Sažetak

The most frequent surgical procedure in oral surgery is extraction of mandibular
third molars, which could be associated with postoperative complications such as pain, swelling, and
trismus. We aimed to investigate the association of salivary urea and antioxidative enzyme activities
with the intensity of postoperative pain after wisdom tooth extraction. This cross-sectional prospective
study included 66 subjects (median age 25, range 17-47 years). Salivary urea and superoxide dismutase
(SOD) were determined by enzymatic colorimetric tests. The questionnaire for study participants
included demographic and history data, as well as data on personal experience of pain in grade 0-10
according to the visual analog scale (VAS). Grading 1-3 was considered as low (VAS-1), 4-6 mild
(VAS-2) and 7-10 as severe pain (VAS-3). Moderate positive correlation was recorded between
urea concentration and SOD activity in saliva (r=0.46). Moderate negative correlations were found
between urea salivary concentration and VAS grading value reported after 12 hours (r=0.51). The
concentrations of urea significantly differed among the three VAS categories (p<0.001), whereas
salivary SOD activities did not differ among the categories. Preoperative salivary urea concentration
and SOD activity might be associated with postsurgical pain after surgical removal of mandibular
third molars.

Ključne riječi

Superoxide dismutase; Urea; Pain; Molar, third; Extraction, tooth

Hrčak ID:

322049

URI

https://hrcak.srce.hr/322049

Datum izdavanja:

1.4.2024.

Podaci na drugim jezicima: hrvatski

Posjeta: 0 *