Izvorni znanstveni članak
https://doi.org/10.20471/acc.2024.63.s2.8
Kidney Transplantation from Deceased Donors with Prostate Cancer
Nikolina Bašić-Jukić
; Department of Nephrology, Arterial hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia
*
Ivana Jurić
; Department of Nephrology, Arterial hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia
Lea Katalinić
; Department of Nephrology, Arterial hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia
Vesna Furić-Čunko
; Department of Nephrology, Arterial hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia
Zoran Sabljić
; Department of Nephrology, Arterial hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia
Armin Atić
; Department of Nephrology, Arterial hypertension, Dialysis and Transplantation, University Hospital Center Zagreb, Zagreb, Croatia
Dinko Hauptman
; Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia
Zoran Zimak
; Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia
Ivica Mokos
; Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia
Tvrtko Hudolin
; Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia
Željko Kaštelan
; Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia
* Dopisni autor.
Sažetak
Introduction: Kidney transplantation is associated with the risk of unrecognized cancer transmission from donor to recipient. There have been no reported cases of prostate cancer transmission in kidney transplantation.
Methods: We conducted a retrospective search of all cadaveric kidney allograft donors from August 2007 to November 2022 with available autopsy findings. Our primary interest were patients diagnosed
with prostate cancer on autopsy. In further analysis, we recorded the data from the recipients of these
kidneys, including further management and malignant disease development.
Results: Overall, there were 1360 kidney transplantations at our center in the studied period. Three
donors were diagnosed with prostate cancer at autopsy. Two recipients received kidney allografts from
donors with a Gleason score 6 for intraprostatic cancer and one from a donor with a Gleason score of 7.
After the appropriate information, all recipients decided to continue renal replacement with transplanted
organs. Patients were switched to an mTOR inhibitor and are currently in regular and meticulous
follow-up.
Conclusion: Prostate cancer may be diagnosed on autopsy, and its prevalence has been increasing
with the age of donors. The risk of transmission should be individually assessed based on the pathology
findings.
Ključne riječi
ŠProstate cancer; Kidney donor; Cancer transmission
Hrčak ID:
323239
URI
Datum izdavanja:
30.4.2024.
Posjeta: 0 *