Stručni rad
https://doi.org/10.20471/acc.2024.63.s2.9
Microbiome and Prostate Cancer
Ivana Mareković
orcid.org/0000-0002-3471-4285
; Clinical Department of Clinical Microbiology, Prevention and Infection Control, University Hospital Centre Zagreb, Zagreb, Croatia; School of Medicine University of Zagreb, Zagreb, Croatia
*
* Dopisni autor.
Sažetak
According to scientific research, the microbiome and the likelihood of developing
cancer are causally related. Current evidence indicates the probable absence of bacteria in a
disease-free prostate. There is still a lack of conclusive evidence linking the diversity of gut microbiota
and prostate cancer. The development and spread of prostate cancer seem to be significantly influenced
by inflammation. With next generation sequencing methods, different bacterial species were found
in the gut microbiome of patients with prostate cancer. The microbiome can affect the effectiveness
of various chemotherapeutic drugs by altering the immune system and metabolic processes. Patients
with and without radiation enteropathy have different microbiomes. The possibility of risk assessment,
prevention, or treatment of radiation-induced enteropathy can be revealed by microbiome testing
before and during pelvic radiation. It is essential to understand the complex relationship between the
microbiome and prostate cancer. The manipulation of gut microbiome may enhance the effectiveness
of cancer treatments. The opportunity to use the microbiome as a target for the prevention of this
cancerous condition as well as an additional intriguing option in the management of prostate cancer
and a more comprehensive therapeutic approach should not be missed.
Ključne riječi
Prostate cancer; Microbiome; Treatment; Prevention; Inflammation
Hrčak ID:
323241
URI
Datum izdavanja:
30.4.2024.
Posjeta: 0 *