Stručni rad
Diagnosis, Investigation and Management of Non-immediate (Type IV) Cutaneous Adverse Drug Reactions
Vesna Vukičević Lazarević
orcid.org/0000-0001-8145-6840
; Special Hospital for Pulmonary Diseases, Zagreb, Croatia
Sažetak
Pathophysiologically, drug hypersensitive reactions (DHRs) are classified into
four types: type I, immediate reactions, and types II, III, and IV, non-immediate
reactions. They are further categorized as severe or non-severe based on clini-
cal severity. Genetic predisposition and viral reactivation are cofactors of severe
DHR type IV. Rapid identification, cessation, and future avoidance of offending
and cross-reactive drugs are the cornerstone of treatment. The diagnosis is es-
tablished based on the history, physical examination, and subsequent in vivo,
in vitro, and drug provocation testing, which are selected based on the severity
of DHR. In non-severe DHRs, desensitization to the offending drug is possible.
Ključne riječi
drug hypersensitive reactions; non-immediate cutaneous adverse reactions; type IV hypersensitivity; diagnosis and management; drug provoca- tion testing
Hrčak ID:
326850
URI
Datum izdavanja:
10.4.2024.
Posjeta: 553 *