Original scientific paper
https://doi.org/10.26332/seemedj.v8i2.338
Viral Infection in Glioblastoma: Immunohistochemistry in Detection of Cytomegalovirus, Epstein-Barr and Herpes Simplex – 1 Virus
Nenad Koruga
orcid.org/0000-0001-7555-1155
; Department of Neurosurgery, University Hospital Center Osijek, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia
*
Tatjana Pekmezović
; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Serbia
Ilijan Tomaš
; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Department of Oncology, University Hospital Center Osijek, Croatia
Jasmina Rajc
; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Department of Pathology and Forensic medicine, University Hospital Center Osijek, Croatia
Alen Rončević
; Department of Neurosurgery, University Hospital Center Osijek, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia
Anamarija Soldo Koruga
; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Department of Neurology, University Hospital Center Osijek, Croatia
* Corresponding author.
Abstract
Introduction: Glioblastoma (GB) is the most aggressive glial tumor of the brain with a dismal prognosis. Studies conducted during the last two decades highlighted neurotropic viruses as a risk factors involved in development of glioblastoma. Authors present an immunohistological study conducted in a single center on sixty-three archive paraffin-embedded samples of GB.
Patients and methods: The tissues were tested using immunohistochemistry in a homogenous group of sixty-three glioblastoma paraffin-embedded tissues for the presence of Cytomegalovirus (CMV), Epstein-Barr virus (EBV) and herpes simplex virus type 1 (HSV-1).
Results: Three species of herpes viruses were tested: HSV-1, Epstein-Barr virus (EBV) and Cytomegalovirus using the standard automatized immunohistochemistry. According to the IRS score, there were six samples of HSV-1 regarded as IRS 2 and five IRS 1 samples of the same virus. EBV and CMV were negative.
Conclusion: The result of our study identified HSV-1 as the most prominent neurotropic virus among population surgically treated of GB. Further studies are necessary to confirm its possible oncomodulatory role.
Keywords
cytomegalovirus; Epstein-Barr virus; Herpes simplex virus; glioblastoma; neurotropic viruses; oncogenic viruses
Hrčak ID:
328021
URI
Publication date:
14.2.2025.
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