Social Psychiatry, Vol. 52 No. 4, 2024.
Review article
https://doi.org/10.24869/spsih.2024.293
Novel Therapeutic Strategies for Treatment-Resistant Depression
Andrijana Šantić
orcid.org/0000-0002-5321-0920
; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Psychiatry, Clinical Hospital Centre Osijek, Osijek, Croatia
Dunja Degmečić
; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Psychiatry, Clinical Hospital Centre Osijek, Osijek, Croatia
Alma Mihaljević-Peleš
; University of Zagreb School of Medicine, Zagreb, Croatia; Department of Psychiatry and Psychological Medicine, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Abstract
Treatment-resistant depression (TRD) is a lack of satisfactory response to standard antidepressant therapy, and poses a
formidable challenge for both patients and clinicians, underscoring the constant need for innovative therapeutic strategies.
This article delves into the therapeutic modalities for TRD, with a focal point on personalized treatment paradigms. We
will describe a new cohort of antidepressants, such as esketamine and the dextromethorphan-bupropion combination,
spotlighting their efficacy in targeting the cerebral glutamate system. Gepirone ER, a selective medication for serotonin
1A receptors, emerges as a promising therapeutic avenue for patients with TRD. In addition to pharmacological therapy,
neuromodulation methodologies such as electroconvulsive therapy (ECT), light therapy and transcranial magnetic
stimulation (TMS), have yielded promising results in the treatment of TRD. Furthermore, hormone therapy, including the
utilization of triiodothyronine (T3) in tandem with other pharmacotherapies, alongside exogenous oxytocin, emerge as
prospective therapeutic options. Upon reviewing the available literature, it is evident that continued research is required
in this domain. This review underscores new insights into the treatment landscape of treatment-resistant depression,
including a new class of medications, neuromodulation techniques, hormone therapy and other substances, as promising
modalities in the battle against TRD.
Keywords
Depressive Disorder; Treatment Resistant Depression; Antidepressants; ICD-11
Hrčak ID:
328110
URI
Publication date:
10.12.2024.
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