Studija slučaja
https://doi.org/10.5671/ca.48.4.7
Diagnostic re-evaluation of “pleural sarcoma” in two wet specimens from the Pathology Collection in the University of Turin
Luisa Ferrari
orcid.org/0000-0003-4588-6215
; Pathology Unit, Cardinal Massaja Hospital, Asti, Italy
Mauro Papotti
; Department of Oncology, Pathology Unit, University of Turin, Torino, Italy
Eleonora Duregon
; Department of Oncology, Pathology Unit, University of Turin, Torino, Italy
Salvatore Micalizio
; Department of Oncology, Pathology Unit, University of Turin, Torino, Italy
Daniela Rullo
; Division of Pathology, San Salvatore Hospital, L’Aquila, Italy
Luana Fegatilli
; Division of Pathology, San Salvatore Hospital, L’Aquila, Italy
Luca Ventura
orcid.org/0000-0002-1526-3941
; Division of Pathology, San Salvatore Hospital, L'Aquila, Italy
Sažetak
Pathology Museums often house fluid-preserved historical specimens. In recent years, the possibility to study such specimens through modern techniques has increased their importance, due to their biological and historical value. The Pathology Collection of Turin houses around 300 wet specimens dating back to the late 19th and early 20th century. The majority of them are still in their original jars, with labels describing year and diagnosis. Two cases of this collection are labeled as “pleural sarcoma”, and date back to years 1896 and 1898. The original post mortem reports are filed in the library of the Pathology Institute of Turin. At present times, primary sarcoma would represent a generical diagnosis and an extremely rare entity in the pleura, where the most common primary neoplasm is malignant mesothelioma. Thus, a diagnostic re-evaluation was carried out, including routine histopathology, and immunohistochemistry, as well as an archive survey of the original reports.The morphological analysis and the available clinical correlates allowed to reclassify such cases as metastatic squamous cell carcinoma from an unknown primary, and pleuro-pulmonary metastases of a uterine leiomyosarcoma.This study suggests that, at the end of 19th century, the post mortem diagnosis of pleural sarcoma encompassed different pathological conditions, often including secondary lesions.
Ključne riječi
pathology museums; wet specimen; lung; sarcoma; histopathology
Hrčak ID:
330161
URI
Datum izdavanja:
20.12.2024.
Posjeta: 0 *