Review article

https://doi.org/10.24869/spsih.2025.73

Benzodiazepine Interactions and Their Clinical Implications

Nika Sutara orcid.org/0009-0001-7191-3187 ; University of Zagreb School of Medicine, Zagreb, Croatia
Marina Šagud ; University of Zagreb School of Medicine, Zagreb, Croatia; Department of Psychiatry and Psychological Medicine, Clinical Hospital Centre Zagreb, Zagreb, Croatia

Abstract

Anxiety disorders are among the most common mental health conditions, with a notable rise in the affected
population in the past few decades. Such changes have led to an increased prescription of anxiolytics, particularly
benzodiazepines. Given that many patients use benzodiazepines alongside other medications, it is crucial to consider
the potential interactions that may occur. The aim of this review article is to provide insight into the pharmacokinetic
and pharmacodynamic interactions of benzodiazepines with various other drugs, with special emphasis on the role of
cytochrome P450 enzymes and the GABA-A receptors. An evaluation of specific drug combinations, their effects on the
metabolism and benzodiazepine action, as well as potential clinical implications, can provide valuable insights when it
comes to making informed clinical decisions and minimizing the risk of adverse drug reactions.

Keywords

Pharmacokinetics; Pharmacodynamics; Drug-Drug Interactions; Benzodiazepines

Hrčak ID:

330217

URI

https://hrcak.srce.hr/330217

Publication date:

26.3.2025.

Article data in other languages: croatian

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