Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2022.63.56 4
No increase in GFAP and S-100B in very preterm infants with mild periventricular leukomalacia or intraventricular hemorrhage: a pilot study
Maša Koce
; University Medical Centre Ljubljana, Ljubljana, Slovenia
Aleš Jerin
; Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Slovenia
Domen Plut
; Institute of Radiology, University Medical Centre Ljubljana, Ljubljana, Slovenia
Vanja Erčulj
; Rho Sigma Research & Statistics, Ljubljana, Slovenia
Lilijana Kornhauser Cerar
; Rho Sigma Research & Statistics, Ljubljana, Slovenia
Stefan Grosek
; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
*
* Dopisni autor.
Sažetak
Aim To determine the serum levels of glial fibrillary acidic
protein (GFAP) and S-100B in very preterm infants with and
without periventricular leukomalacia (PVL) and/or intra
-
ventricular hemorrhage (IVH).
Methods The study enrolled preterm infants born be
-
tween 23 and 32 weeks of gestation admitted to the Neo
-
natal Intensive Care Unit, University Medical Center Ljublja
-
na. PVL and IVH were determined with cranial ultrasound.
Peripheral blood was collected in the first 24 hours after
delivery and once between days 4 to 7. GFAP and S-100B
concentrations were measured in serum samples. Infants
with PVL or IVH were compared with infants without PVL
or IVH.
Results Of 40 patients (mean gestational age 29.4 weeks),
7 had IVH and/or PVL. S-100B was detectable in peripheral
blood in all patients at every measurement. In the group
with IVH or PVL, the median S-100B at the first sampling
was 0.43 (IQR 0.29-0.60) ng/mL, and 0.40 (IQR 0.33-1.01)
ng/mL at the second sampling. In the group without PVL
or IVH, it was 0.40 (IQR 0.29-0.6) ng/mL at the first sampling
and 0.43 (IQR 0.34-0.62) ng/mL at the second sampling.
The median GFAP was 0 regardless of the group and sam
-
pling time. The groups did not significantly differ in serum
GFAP or S-100B levels.
Conclusion Peripheral blood levels of GFAP and S-100B
were not significantly increased in very preterm infants
that developed PVL or IVH. The predictive value of GFAP
and S-100B as biomarkers of neonatal brain injury should
be further explored in a larger cohort of neonates with
more extensive IVH or PVL.
Ključne riječi
Hrčak ID:
331078
URI
Datum izdavanja:
15.12.2022.
Posjeta: 248 *