Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2023.64.1 3
The performance of the WHO COVID-19 severity classification, COVID-GRAM, VACO Index, 4C Mortality, and CURB-65 prognostic scores in hospitalized COVID-19 patients: data on 4014 patients from a tertiary center registry
Marko Lucijanić
; Hematology Department, Dubrava, University Hospital, Zagreb, Croatia
*
Nevenka Piskač Živković
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
Tanja Režić
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
Ivan Durlen
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
Josip Stojić
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
Ivana Jurin
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
Sara Šakota
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
Dora Filipović
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
Iva Kurjaković
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
Ana Jordan
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
Nikolina Bušić
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
Josipa Pavić
; Department of Medical Biochemistry and Hematology Laboratory, Livno General County Hospital, Livno, Bosnia and Herzegovina
Ivica Lukšić
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
Bruno Baršić
; Primary Respiratory and Intensive Care Center, Dubrava University Hospital, Zagreb, Croatia
* Dopisni autor.
Sažetak
Aim To evaluate the predictive properties of several com
-
mon prognostic scores regarding survival outcomes in
hospitalized COVID-19 patients.
Methods We retrospectively reviewed the medical records
of 4014 consecutive COVID-19 patients hospitalized in our
tertiary level institution from March 2020 to March 2021.
Prognostic properties of the WHO COVID-19 severity clas
-
sification, COVID-GRAM, Veterans Health Administration
COVID-19 (VACO) Index, 4C Mortality Score, and CURB65 score regarding 30-day mortality, in-hospital mortality,
presence of severe or critical disease on admission, need
for an intensive care unit treatment, and mechanical venti
-
lation during hospitalization were evaluated.
Results All of the investigated prognostic scores signifi
-
cantly distinguished between groups of patients with differ
-
ent 30-day mortality. The CURB-65 and 4C Mortality Score
had the best prognostic properties for prediction of 30-day
mortality (area under the curve [AUC] 0.761 for both) and
in-hospital mortality (AUC 0.757 and 0.762, respectively).
The 4C Mortality Score and COVID-GRAM best predicted
the presence of severe or critical disease (AUC 0.785 and
0.717, respectively). In the multivariate analysis evaluating
30-day mortality, all scores mutually independently provid
-
ed additional prognostic information, except the VACO In
-
dex, whose prognostic properties were redundant.
Conclusion Complex prognostic scores based on many
parameters and comorbid conditions did not have better
prognostic properties regarding survival outcomes than a
simple CURB-65 prognostic score. CURB-65 also provides
the largest number of prognostic categories (five), allowing
more precise risk stratification than other prognostic scores.
Ključne riječi
Hrčak ID:
331244
URI
Datum izdavanja:
1.3.2023.
Posjeta: 306 *