Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2023.64.307
Pathohistological features of the aging human lacrimal gland
Koraljka Hat
; Department of Maxillofacial and Oral Surgery, University Hospital Dubrava, Zagreb, Croatia
*
Snježana Kaštelan
; Department of Ophthalmology, University Hospital Dubrava, Zagreb, Croatia
Ana Planinić
; Department of Histology and Embryology, University of Zagreb School of Medicine, Zagreb, Croatia
Danko Muller
; Clinical Department of Pathology and Cytology, University Hospital Dubrava, Zagreb, Croatia
Davor Ježek
; Department of Histology and Embryology, University of Zagreb School of Medicine, Zagreb, Croatia
* Dopisni autor.
Sažetak
Aim To assess sex-related differences in the pathohistological features of the human lacrimal gland and to investigate age-related and sex-related differences in stereologically measured volume density of the secretory tissue,
connective tissue, and fat.
Methods We performed an observational analysis of acinar
atrophy, periacinar fibrosis, periductal fibrosis, ductal dilation, ductal proliferation, fatty infiltration, and lymphocyte
infiltration of hematoxylin and eosin-stained lacrimal gland
samples from 81 cornea donors. Stereological analysis of
the volume density of the secretory tissue, connective tissue, and fat was performed on samples from 66 donors.
Results Up to 69% of all samples showed degenerative
changes. Female samples had a higher frequency of all observed degenerative changes, except ductal dilation. While
acinar atrophy was significantly more prevalent in women,
ductal dilation was significantly more prevalent in men.
Stereological analysis indicated lower portions of acini and
higher portions of connective tissue and fat, as well as a
more pronounced age-related progression of degenerative changes in female samples.
Conclusion Female lacrimal glands are more susceptible
to degeneration, and this susceptibility could play an important role in the higher incidence of dry eye disease in
older women. A further stereological analysis using more
samples from younger age groups is needed to elucidate
age-related and sex-related differences in the structure
of the human lacrimal gland and their impact on dry eye
disease
Ključne riječi
Hrčak ID:
331848
URI
Datum izdavanja:
30.9.2024.
Posjeta: 37 *