Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2023.64.320
Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth
Aleksandra Fučić
; Institute for Medical Research and Occupational Health, Zagreb, Croatia
*
Jelena Knežević
; Srebrnjak Children’s Hospital, Zagreb, Croatia
Jure Krasić
; Scientific Center of Excellence for Reproductive and Regenerative Medicine (CERRM), University of Zagreb School of Medicine, Zagreb, Croatia
Denis Polančec
; Srebrnjak Children’s Hospital, Zagreb, Croatia
Nino Sinčić
; Scientific Center of Excellence for Reproductive and Regenerative Medicine (CERRM), University of Zagreb School of Medicine, Zagreb, Croatia
Nada Sindičić Dessardo
; University Hospital Center Zagreb, Zagreb, Croatia
Mirta Starčević
; University Hospital Center Zagreb, Zagreb, Croatia
Vedrana Guszak
; University Hospital Center Zagreb, Zagreb, Croatia
Marcello Ceppi
; University Hospital Center Zagreb, Zagreb, Croatia
Marco Bruzzone
; IRCCS Ospedale Policlinico San Martino, Genova, Italy
* Dopisni autor.
Sažetak
Aim To compare interleukin-2 levels (IL-2) and IL-2 gene
site 1 methylation levels between preterm newborns (PN)
and full-term newborns (FN) and investigate their association with the environmental exposure of their mothers
during pregnancy.
Methods IL-2 and IL-2 gene site 1 methylation levels were
assessed in 50 PN and 56 FN. Newborns’ mothers filled in
questionnaires about their living and occupational environments, habits, diets, and hobbies.
Results The mothers of PN were significantly more frequently agrarian/rural residents than the mothers of FN.
PN had significantly higher IL-2 levels, and significantly
lower methylation of IL-2 gene site 1 levels than FN.
Conclusion IL-2 levels, hypomethylation of the IL-2 gene
site 1, and the mother’s rural residence (probably due to
pesticide exposure) were predictive biomarkers for preterm
birth. For the first time, we present the reference values for
the methylation of IL-2 gene site 1 in PN and FN, which can
be used in the clinical setting and biomonitoring.
Ključne riječi
Hrčak ID:
331867
URI
Datum izdavanja:
30.9.2024.
Posjeta: 38 *