Stručni rad
https://doi.org/10.3325/cmj.2023.64.344
Increased carotid intima-media thickness is associated with higher odds of unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia: a nested case-control study
Miljenko Crnjaković
; Dubrava University Hospital, Zagreb, Croatia
Sabina Deveđija
; Dubrava University Hospital, Zagreb, Croatia
Gorana Vukorepa
; Dubrava University Hospital, Zagreb, Croatia
Stela Rutović
; Dubrava University Hospital, Zagreb, Croatia
Davor Sporiš
; Dubrava University Hospital, Zagreb, Croatia
Vladimir Trkulja
; Department of Pharmacology, Zagreb University School of Medicine, Zagreb, Croatia
*
* Dopisni autor.
Sažetak
Aim To evaluate the association between carotid intimamedia thickness (CIMT) at hospital admission and unfavorable outcomes in adults without advanced vascular diseases presenting with non-severe COVID-19 pneumonia
to assess the feasibility of evaluating CIMT as a risk stratification aid in this setting.
Methods This proof-of-concept nested case-control study
enrolled consecutive non-vaccinated adults free of advanced vascular diseases presenting with verified non-severe COVID-19 pneumonia between December 2020 and
June 2021. CIMT was measured at admission, and patients
were managed in line with the national Ministry of Health
guidelines. Those who died or required mechanical ventilation (MV) during the index hospital stay were considered
cases and were matched (entropy balancing, exact matching) on a set of covariates to survivors not requiring MV
(controls). Frequentist and Bayesian logistic models were
fitted to the case status.
Results The study enrolled 207 patients: 27 (13%) cases
and 180 controls. All were retained in the analysis after entropy balancing, while 27 cases were exactly matched to
99 controls. Higher CIMT at the proximal internal carotid artery (both left and right) was consistently associated with
higher odds of being a case: all odds ratio point-estimates
were ≥1.50 with lower limits of the 99% confidence intervals/credibility intervals ≥1.00 with two-sided probabilities
of OR>1.00 greater than 99.5%. The susceptibility of the estimates to unmeasured confounding was low.
Conclusion This study supports the feasibility of CIMT as a
risk stratification aid in adults free of advanced vascular disease presenting with non-severe COVID-19 pneumon
Ključne riječi
Hrčak ID:
331872
URI
Datum izdavanja:
30.9.2024.
Posjeta: 39 *