Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2024.65.220
Association of ACE2 and TMPRSS2 genes variants with disease severity and most important biomarkers in COVID19 patients in Bosnia and Herzegovina
Neven Meseldžić
; Department of Pharmaceutical Biochemistry and Laboratory Diagnostics, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Besim Prnjavorac
; General Hospital Tešanj, Tešanj, Bosnia and Herzegovina
Tanja Dujić
; Department of Pharmaceutical Biochemistry and Laboratory Diagnostics, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Maja Malenica
; Department of Pharmaceutical Biochemistry and Laboratory Diagnostics, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Una Glamočlija
; Department of Pharmaceutical Biochemistry and Laboratory Diagnostics, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Lejla Prnjavorac
; General Hospital Tešanj, Tešanj, Bosnia and Herzegovina
Omer Bedak
; General Hospital Tešanj, Tešanj, Bosnia and Herzegovina
Selma Imamović Kadrić
; Department of Pharmaceutical Biochemistry and Laboratory Diagnostics, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Damir Marjanović
; Department of Genetics and Bioengineering, International Burch University, Sarajevo, Bosnia and Herzegovina
Tamer Bego
; Department of Pharmaceutical Biochemistry and Laboratory Diagnostics, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
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* Dopisni autor.
Sažetak
Aim To assess the association of single nucleotide poly
-
morphisms (SNPs) in the ACE2 and TMPRSS2 genes with
COVID-19 severity and key biomarkers.
Methods The study involved 750 COVID-19 patients from
Bosnia and Herzegovina, divided into three groups: mild,
moderate, and severe cases. Genetic variations within the
ACE2 (rs2285666) and TMPRSS2 (rs2070788) genes were
examined with real-time polymerase chain reaction. Bio
-
chemical markers were determined with standard proce
-
dures.
Results There was a significant difference in the rs2070788
genotype distribution between patients with mild and
moderate symptoms, but not between other groups. For
the rs2285666 polymorphism, no significant difference in
genotype distribution was found. In patients with mild
symptoms, carriers of the GG genotype of rs2070788 had
significantly higher total bilirubin levels than carriers of
the AA genotype. Similarly, carriers of the TT genotype of
rs2285666 had significantly higher activated partial throm
-
boplastin time and international normalized ratio, and
lower lactate dehydrogenase levels compared with the CC
genotype. Among patients with severe symptoms, carriers
of the GG genotype showed significantly higher potassi
-
um levels than carriers of the AA genotype, while carriers
of the TT genotype showed significantly higher erythro
-
cyte count as well as hemoglobin and hematocrit levels
compared with the CC genotype.
Conclusion This study highlights the role of genetic fac
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tors, particularly SNPs in the ACE2 and TMPRSS2 genes, in
determining COVID-19 severity, aiding patient risk assess
-
ment and prognosis.
Ključne riječi
Hrčak ID:
332022
URI
Datum izdavanja:
16.6.2024.
Posjeta: 36 *