Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2024.65.249
Dense single nucleotide polymorphism testing revolutionizes scope and degree of certainty for source attribution in forensic investigations
Sammed N. Mandape
; Othram Inc., The Woodlands, TX, USA
Bruce Budowle
; Department of Forensic Medicine, University of Helsinki, Helsinki, Finland
Kristen Mittelman
; Othram Inc., The Woodlands, TX, USA
David Mittelman
; Othram Inc., The Woodlands, TX, USA
*
* Dopisni autor.
Sažetak
The field of forensic DNA analysis has experienced significant advancements over the years, such as the advent of
DNA fingerprinting, the introduction of the polymerase
chain reaction for increased sensitivity, the shift to a primary genetic marker system based on short tandem repeats,
and implementation of national DNA databases. Now, the
forensics field is poised for another revolution with the
advent of dense single nucleotide polymorphisms (SNPs)
testing. SNP testing holds the potential to significantly
enhance source attribution in forensic cases, particularly
those involving low-quantity or low-quality samples. When
coupled with genetic genealogy and kinship analysis, it
can resolve countless active cases as well as cold cases and
cases of unidentified human remains, which are hindered
by the limitations of existing forensic capabilities that fail to
generate viable investigative leads with DNA. The field of
forensic genetic genealogy combined with genome-wide
sequencing can associate relatives as distant as the seventh-degree and beyond. By leveraging volunteer-populated databases to locate near and distant relatives, genetic
genealogy can effectively narrow the candidates linked to
crime scene evidence or aid in determining the identity
of human remains. With decreasing DNA sequencing costs
and improving sensitivity of detection, forensic genetic genealogy is expanding its capabilities to generate investigative leads from a wide range of biological evidence.
Ključne riječi
Hrčak ID:
332025
URI
Datum izdavanja:
16.6.2024.
Posjeta: 30 *