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https://doi.org/10.24099/vet.arhiv.2618

Procjena hepatorenalnog oštećenja uzrokovanog benzil peniciloinskom kiselinom u miševa

Ruixue Hu ; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, China
Jian Guo ; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, China
Ke Zhao ; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, China
Honglin Ren ; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, China
Zengshan Liu ; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, China
Shiying Lu ; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, China
Yansong Li ; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, China
Yang Wang ; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, China
Pan Hu ; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, China *

* Dopisni autor.

Sažetak

Benzil peniciloinska kiselina (BPNLA) jest nusprodukt prirodne razgradnje i enzimske hidrolize penicilina. BPNLA u ljudsko tijelo ulazi i nakuplja se ponajprije konzumacijom životinjskih proizvoda. Dosadašnja su istraživanja uglavnom bila usredotočena na rezistenciju na lijek i posljedične alergijske reakcije, no kako se akumulacija lijeka povećava, tako se očituje i toksičnost. Jetra i bubrezi glavni su organi u kojima se metabolizira lijek te su i najviše izloženi toksičnim učincima, stoga je cilj istraživanja bio ispitati hepatorenalnu toksičnost BPNLA. Svi miševi C57BL/6 nasumično su raspoređeni u četiri skupine te im je oralno primjenjivana BPNLA u dozi od 2,925, 146,25 i 7312.5 μg/kg tjelesne mase ili ekvivalentna količina fiziološke otopine (kontrolna skupina) tijekom 35 dana. Rezultati su pokazali da BPNLA može sniziti organski koeficijent jetre te dovesti do strukturnih abnormalnosti u jetri i bubrezima. Daljnja su istraživanja pokazala da su se vrijednosti pokazatelja funkcije jetre i bubrega te lipidne peroksidacije (MDA), kao i proupalnih citokina (TNF-α i IL-1β), u pokusnim skupinama povećale u usporedbi s kontrolnom skupinom. Štoviše, razine antioksidacijskih enzima (GSH, SOD, GPX) smanjivale su se u pokusnim skupinama, ovisno o doziranju BPNLA. Rezultati su jasno pokazali da čak i relativno niske koncentracije BPNLA mogu uzrokovati oštećenje jetre i bubrega, što bi trebalo izazvati zabrinutost u pogledu izloženosti ljudi BPNLA-i.

Ključne riječi

benzil peniciloinska kiselina; hepatorenalna toksičnost; lipidna peroksidacija; oksidacijski stres; upala

Hrčak ID:

334253

URI

https://hrcak.srce.hr/334253

Datum izdavanja:

1.7.2025.

Podaci na drugim jezicima: engleski

Posjeta: 516 *