Stručni rad
Livedoid Vasculopathy in a Female Patient With a History of COVID-19 Infection During Pregnancy: A Case Report
Iva Domić
orcid.org/0000-0001-5292-6217
; Dubrava University Hospital, Zagreb, Croatia
*
Ilenia Romić
; Dubrovnik General Hospital, Dubrovnik, Croatia
Majda Vrkic Kirhmajer
orcid.org/0000-0002-1340-1917
; University Hospital Centre Zagreb, Zagreb, Croatia
Joško Mitrović
orcid.org/0000-0001-9190-7828
; Dubrava University Hospital, Zagreb, Croatia
Jadranka Morović-Vergles
; Division of Clinical Immunology, Allergology and Rheumatology, Department of Internal Medicine, Dubrava University Hospital, Zagreb, Croatia
* Dopisni autor.
Sažetak
Livedoid vasculopathy is a rare, chronic thrombo-occlusive disease characterized
by recurrent livedoid skin changes, atrophic white plaques, and ulceration. It
most commonly affects the dermal vessels of the distal lower extremities, ankles, and
feet, bilaterally. While it is commonly associated with hypercoagulable states, systemic
autoimmune diseases, and malignancies, we report a case of a previously healthy
31-year-old female with a history of moderate COVID-19 infection during pregnancy,
two years before the onset of livedoid skin changes.
The patient presented to a hematologist with a two-month history of erythematous to
violaceous macules and patches on the dorsum of the feet, ankles, and lower extremities,
along with mild ankle swelling. Multiple punch biopsies of the affected skin demonstrated
thrombi, fibrinoid vascular changes, fibrosis, and hyalinization of the vessel
walls – findings consistent with vasculopathy. Initial treatment included subcutaneous
low-molecule weight heparin (dalteparin).
This case highlights the importance of early recognition, the performance of a skin
biopsy with subsequent histopathologic diagnosis, and appropriate management of
this rare, but potentially debilitating condition
Ključne riječi
livedoid vasculopathy; pregnancy; COVID-19 infection; anticoagulation therapy
Hrčak ID:
346961
URI
Datum izdavanja:
22.6.2025.
Posjeta: 0 *