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THE GENETIC BASIS OF ALLERGIC DISEASES

Irena Ivković Jureković ; Klinika za dječje bolesti Zagreb, klinika za pedijatriju, odjel za pulmologiju, alergologiju i reumatologiju s kliničkom imunologijom, Klaićeva 16, 10 000 Zagreb

Sažetak

There are over 100 genes that have been reported to be associated with atopy, asthma or related phenotypes. Like other atopic diseases, asthma is a complex disorder caused by interactions between multiple genes of small or modest effect and equally important environmental factors. Asthma and atopic diseases have an important genetic component but no clear pattern of inheritance. Replication of genetic associations and demonstration of a functional link between the associated variants and disease are required to confirm atopy and asthma susceptibility genes. Certain important recently detected genes which were replicated by independent association studies and have functional data are reviewed in this article.

Ključne riječi

Descriptors: HYPERSENSITIVITY, IMMEDIATE – genetics; ASTHMA – genetics; GENETIC PREDISPOSITION TO DISEASE

Hrčak ID:

34969

URI

https://hrcak.srce.hr/34969

Datum izdavanja:

9.3.2009.

Podaci na drugim jezicima: hrvatski

Posjeta: 3.785 *