Sažetak sa skupa
Oral Squamous Cell Carcinoma (OSCCA) Arising from an Oral Lichen Planus Lesion - Report of Two Cases
Marinka Mravak-Stipetić
Irina Filipović-Zore
Ahmed Pirkić
S. Manojlović
Mišo Virag
Sažetak
The risk of malignant transformation of oral lichen planus remains a controversial issue in the literature. Chronicity of oral lesions has been shown to present low risk of oral cancer which has been identified as arising from areas of erythematous atrophic and erosive lichen planus. It is estimated that malignant transformation of OLP occurs in 0.4 - 2.5% of cases, mostly those with lichenoid dysplasia. Recent molecular genetic studies showed minimal genetic deviation in lesions of oral lichen planus, while the epithelial dysplasia and alignant lesions have shown increased genetic alterations.
We report two well-documented cases of long-standing oral lichen planus in which squamous cell carcinoma of the buccal mucosa occurred.
Presented cases document and warn of the propensity of oral lichen planus to undergo malignant transformation and stresses the importance of regular histilogical follow up; biopsy at the initial visit to confirm the diagnosis and more frequent control biopsies during clinical follow up to assess histological changes that may represent dysplasia. As a lesion at risk malignant transformation, OLP also needs to be confirmed by use of genetic markers.
Ključne riječi
Hrčak ID:
3450
URI
Datum izdavanja:
15.9.2003.
Posjeta: 2.107 *