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Anthelmintic screening of fractions of Spigelia anthelmia Linn extracts against experimental Nippostrongylus braziliensis in rats

Olorunfemi Cornelius Jegede ; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, University of Abuja, Abuja, Nigeria
Rowland Ibrahim Shehu Agbede ; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Joseph Ologunja Ajanusi ; Department of Veterinary Parasitology and Entomology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria
Ambrose Osematta Adaudi ; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria


Puni tekst: engleski pdf 189 Kb

str. 189-197

preuzimanja: 906

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Sažetak

This study was undertaken to screen fractions of extracts of Spigelia anthelmia to fi nd out its anthelmintic activity against experimental Nippostrongylus braziliensis infection in rats. 1000 g of the ethanolic crude extract of Spigelia anthelmia yielded 199 g (19.9%) while fractionation with chloroform, water and ethylacetate yielded 120 g (60%), 64 (32%) and 9 g (4.5%) respectively. In the anthelmintic trial in rats, the aqueous and ethylacetate fractions gave a highly signifi cant (P<0.001) deparasitization; while the chloroform fraction gave non-significant (P>0.05) deparasitization when compared with the control. However, comparing the fractions with each other, chloroform and ethylacetate fractions gave a non signifi cant (P>0.05) deparasitization while the aqueous fraction gave a highly signifi cant (P<0.001) deparasitization. The aqueous fraction was therefore found to possess the active anthelmintic ingredient.

Ključne riječi

Spigelia anthelmia; anthelmintic; Nippostrongylus braziliensis; rats

Hrčak ID:

37428

URI

https://hrcak.srce.hr/37428

Datum izdavanja:

20.4.2009.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.887 *