Veterinarski arhiv, Vol. 75 No. 3, 2005.
Izvorni znanstveni članak
Influence of hypothermia and acidosis upon some indices of blood coagulation in three schemes of anaesthesia in dogs
Galina Petkova Simeonova
; Department of Veterinary Surgery, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
Dinco Nedev Dinev
; Department of Veterinary Surgery, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
Irina Ivanova Todorova
; Department of Veterinary Surgery, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria
Sažetak
The aim of the present study was to investigate the influence of hypothermia and acidosis on blood coagulation in different anaesthesia protocols. Our experiment was performed with 28 dogs, divided into four groups: three experimental submitted to inhalation, balanced, and epidural anaesthesia and one control. In all animals blood pH, core body temperature and some principal parameters of blood coagulation (platelet count, activated partial prothrombine time-APPT, prothrombine time-PT and plasma fibrinogen concentrations) were investigated. The dynamics included five periods; prior to anaesthesia (0th minute), at the time of pre-medication (30th minute), during deep anaesthesia (120th minute), after recovery (about 140th minute), and on the next day (24th hour). The results indicated that the most significant were changes in balanced anaesthesia. APPT was shortened after recovery from balanced anaesthesia (14.1 ± 0.9 seconds, P<0.05) and on the next day (14.5 ± 0.7, P<0.05) compared to the initial value (16.1 ± 0.5). The most pronounced acidosis in this group was recorded during deep anaesthesia (7.126 ± 0.041, P<0.001) and after recovery (7.241 ± 0.028, P<0.05) by comparison with the baseline (7.312 ± 0.008). Parameters of blood coagulation in inhalation anaesthesia group were unchanged. Statistically significant alterations in blood pH were observed only during the deep anaesthesia stage (7.199 ± 0.049, P<0.01) compared to the beginning (7.316 ± 0.006). Epidural anaesthesia did not result in blood pH and coagulation changes. In this group an increase in fibrinogen concentrations at 24th hour (3.7 ± 0.2, P<0.05) were found, compared to the baseline (3.1 ± 0.2), which was probably due to the intervention. In the three groups the core body temperature was decreased at the 120th minute and 140th minute. In conclusion, balanced anaesthesia activated blood coagulation at the 140th minute and 24th hour, which was manifested by a shortening in APPT at these periods. Hypothermia and acidosis accompanying balanced and inhalation anaesthesia groups, as well as hypothermia in epidural anaesthesia had no influence upon blood coagulation parameters.
Ključne riječi
anaesthesia; blood coagulation; hypothermia; acidosis; dog
Hrčak ID:
37435
URI
Datum izdavanja:
20.6.2005.
Posjeta: 1.761 *