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Prospective Surveillance of Croatian Pregnant Women on Lamotrigine Monotherapy - Aspects of Pre-Pregnancy Counseling and Drug Monitoring

Snježana Miškov
Romana Gjergja-Juraški
Ljerka Cvitanović-Šojat
Tomislav Ivičević Bakulić
Aleksandra Fučić
Marija Bošnjak-Pašić
Ivan Mikula
Vida Demarin


Puni tekst: engleski pdf 4.475 Kb

str. 271-280

preuzimanja: 827

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Sažetak

We prospectively surveyed 23 pregnant women with epilepsy on lamotrigine monotherapy and reported outcome of their pregnancies, including one fetal intrauterine death, one spontaneous abortion and two preterm deliveries. There were no congenital malformations in their offspring. Women with pregnancy planning and folic acid intake delivered babies with higher values of birth weight and birth length. There was large inter-patient variation during drug monitoring and in the need of dose adjustment. Individual approach to every woman and monotherapy with minimal effective lamotrigine dose with frequent drug monitoring enhances the possibility for successful pregnancy. The management of women with epilepsy should begin with pre-pregnancy counseling. Planned pregnancy enables periconceptional folic acid supplementation. Despite the small number of cases, these data indicate that lamotrigine treatment during pregnancy might be relatively safe. Larger prospective studies are needed to obtain adequate power for statistical analysis including long-term cohort studies.

Ključne riječi

Pregnancy - complications, Pregnancy - drug therapy, Epilepsy - drug therapy, Epilepsy - metabolism, Anticonvulsants -blood

Hrčak ID:

45142

URI

https://hrcak.srce.hr/45142

Podaci na drugim jezicima: hrvatski

Posjeta: 1.601 *