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Recenzija, Prikaz slučaja

Parkinson's disease

Raphael Béné
Sonja Antić
Mislav Budišić
Marijana Lisak
Zlatko Trkanjec
Vida Demarin
Slava Podobnik-Šarkanji


Puni tekst: engleski pdf 1.560 Kb

str. 377-379

preuzimanja: 4.881

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Sažetak

Parkinson's disease is one of the most common neurodegenerative diseases caused by degeneration of dopaminergic neurons in substantia nigra. The neuropathologic hallmark of Parkinson's disease is the presence of Lewy bodies composed mostly of alpha-synuclein and ubiquitin. It is believed that the occurrence of Parkinson's disease is due to a combination of genetic and environmental factors, but the exact mechanism of Parkinson's disease development is not fully elucidated. The most characteristic motor symptoms for Parkinson's disease include bradykinesia, rigidity, resting tremor and postural instability, while many patients also have non-motor signs and symptoms. The key therapeutic agent in the treatment of Parkinson's disease is L-dopa, and the others are dopaminergic agents, monoamine oxidase-B (MAO-B) inhibitors, catechol-O-methyl transferase (COMT) inhibitors, amantadine and anticholinergic agents.

Ključne riječi

Parkinson disease - etiology, Parkinson disease - diagnosis, Parkinson disease - therapy

Hrčak ID:

45288

URI

https://hrcak.srce.hr/45288

Podaci na drugim jezicima: hrvatski

Posjeta: 6.771 *