Acta clinica Croatica, Vol. 48 No. 3, 2009.
Case report
Parkinson's disease
Raphael Béné
Sonja Antić
Mislav Budišić
Marijana Lisak
Zlatko Trkanjec
Vida Demarin
Slava Podobnik-Šarkanji
Abstract
Parkinson's disease is one of the most common neurodegenerative diseases caused by degeneration of dopaminergic neurons in substantia nigra. The neuropathologic hallmark of Parkinson's disease is the presence of Lewy bodies composed mostly of alpha-synuclein and ubiquitin. It is believed that the occurrence of Parkinson's disease is due to a combination of genetic and environmental factors, but the exact mechanism of Parkinson's disease development is not fully elucidated. The most characteristic motor symptoms for Parkinson's disease include bradykinesia, rigidity, resting tremor and postural instability, while many patients also have non-motor signs and symptoms. The key therapeutic agent in the treatment of Parkinson's disease is L-dopa, and the others are dopaminergic agents, monoamine oxidase-B (MAO-B) inhibitors, catechol-O-methyl transferase (COMT) inhibitors, amantadine and anticholinergic agents.
Keywords
Parkinson disease - etiology; Parkinson disease - diagnosis; Parkinson disease - therapy
Hrčak ID:
45288
URI
Publication date:
1.9.2009.
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