Pregledni rad

NEW GENERATION VS. FIRST GENERATION ANTIPSYCHOTICS DEBATE: PRAGMATIC CLINICAL TRIALS AND PRACTICE-BASED EVIDENCE

Miro Jakovljević ; University Department of Psychiatry, Clinical Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia

Sažetak

There has been significant confusion about the relative advantage of new generation antipsychotics over first generation antipsychotics as well as of clinical trials performed to evaluate their efficacy vs. those designed to evaluate their effectiveness. Pragmatic or effectiveness clinical trials like CATIE and CUtLASS sponsored by governments have challenged the current worldview of the greater advantages of new generation over first generation antipsychotics and suggested
more clinical applicability of older antipsychotics. Public policy regarding the role and place of modern antipsychotics in schizophrenia treatment is usually guided by the imperfect state of clinical trials and by economic constraints. The right question
is not whether new generation antipsychotics are better than first generation antipsychotics in terms of effectiveness, tolerability and safety. How to reach personalized , evidence based and value oriented decision making in the complex treatment of schizophrenia and other psychotic disorders, that is the question now.
Personalized medicine in psychiatry is not possible without the availability of enough number of different modern antipsychotics.

Ključne riječi

antipsychotics; effectiveness; clinical trials; personalized medicine

Hrčak ID:

49565

URI

https://hrcak.srce.hr/49565

Datum izdavanja:

25.8.2009.

Posjeta: 2.045 *