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Lymphomatoid Granulomatosis in a 23-year-old Man – Cytological and Histological Typing and Rapid Response to Steroid and Cyclophosphamide Combination Therapy

Neven Rakušić ; University Hospital for Lung Diseases »Jordanovac«, Zagreb, Croatia
Diana Krmpotić ; University Hospital for Lung Diseases »Jordanovac«, Zagreb, Croatia
Ana Hećimović ; University Hospital for Lung Diseases »Jordanovac«, Zagreb, Croatia
Zagorka Boras ; University Hospital for Lung Diseases »Jordanovac«, Zagreb, Croatia
Božica Vrabec-Branica ; University Hospital for Lung Diseases »Jordanovac«, Zagreb, Croatia
Sonja Džebro
Nevena Rakušić ; University of Zagreb, School of Medicine, Zagreb, Croatia
Tomislav Rešković ; University of Rijeka, School of Medicine, Rijeka, Croatia
Nika Rakušić ; University of Rijeka, School of Medicine, Rijeka, Croatia


Puni tekst: engleski pdf 319 Kb

str. 279-283

preuzimanja: 458

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Sažetak

Lymphomatoid granulomatosis (LG) is currently called as extranodal angiocentric and angiodestructive immunoproliferative disorder with various degrees of histological differentiation and disease severity. Histological grading and clinical manifestations are due to number of atypical large EBV+ B-lymphatic cells. We report the case of a 23-year-old man clinically presented with fever, sweating, and physical intolerance, and bilateral pulmonary infiltrates of nodular type and destructive changes on the chest X-ray, previously treated with antituberculotics for 1.5 month. As the disease showed progression, diagnostic procedures extended to transbronchial lung biopsy and percutaneous fine needle aspiration with cytological and histological analysis of collected specimens, all being not conclusive enough. LG was confirmed by open lung biopsy, followed by induction of corticosteroids and cyclophosphamide therapy. Very good clinical, functional and radiomorphologic improvement was achieved in a few weeks, and remission of disease maintained in long term follow-up.

Ključne riječi

lymphomatoid granulomatosis, pulmonary nodular infiltrates, open lung biopsy, EBV+ B-lymphatic cells

Hrčak ID:

51279

URI

https://hrcak.srce.hr/51279

Posjeta: 974 *