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Metabolic and Physico-chemical Urolithiasis Parameters in the First Morning Urine

Vatroslav Šerić ; Department of Medical Biochemistry, University Hospital Centre Osijek, Osijek, Croatia
Maja Dutour-Sikirić ; »Ruđer Bošković« Institute, Zagreb, Croatia
Ivan Mihaljević ; Clinical Institute of Nuclear Medicine and Radiation Protection, University Hospital Centre Osijek, Osijek, Croatia
Sandra Tucak-Zorić ; City Office for Energetics, Environmental Protection and Sustainable Development, Zagreb, Croatia
Ines Bilić-]určić ; Department for Mineral Metabolism, School of Medicine, University »Josip Juraj Strossmayer«, Osijek, Croatia
Vesna Babić-Ivančić ; Department of Medical Biochemistry, University Hospital Centre Osijek, Osijek, Croatia

Puni tekst: engleski pdf 79 Kb

str. 85-92

preuzimanja: 536



The 24-hour urine is golden standard for metabolic assessment of stone formers. However, due to the difficulties in collecting almost 1/3 of the samples can not be used for the analysis. Therefore, we analyzed first morning urine and calculated different risk indexes in order to asses possibility of using it in determining urolithiasis risk. Subjects were divided into 4 groups: male patients (n=31, age 18–64), female patients (n=31, age 25–63), male controls (n=16, age 25–64) and female controls (n=19, age 21–65). First morning urine pH, concentrations of calcium, magnesium, phosphate, sodium, potassium, chloride, citrate, urate, oxalate, creatinine and glycosaminoglycans were determined. Based on them, ionic concentrations and activity products of calcium oxalate and phosphate were calculated by EQUIL 2. In addition, different risk indices were calculated. The results showed that both patients and control groups had metabolic disorders, but the frequencies of occurrence were statistically independent. Significant difference in concentration of urinary constituents between corresponding patient and control groups was observed only for glycosaminoglycans in female subjects. Ca/Cit ratio and Baggio index could differentiate between both corresponding patients and control groups. The results indicate that interplay between stone formation inhibitors and promotors is responsible for urinary stone formation and that the first morning urine could be used in assessing urolithiasis risk and its prevention.

Ključne riječi

urinary stone formation; first morning urine; metabolic urine disorders; glycosaminoglycans; risk indices

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