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Intravitreal Bevacizumab with or Without Triamcinolone for Refractory Diabetic Macular Oedema
Svatopluk Synek
; Department of Ophthalmology and Optometry, Saint Anne Hospital, Medical Faculty Masaryk University, Brno, Czech Republic
Božo Vojniković
; Daily Eye Clinic »Dr. Božo Vojniković«, Rijeka, Croatia
Sažetak
We evaluate the effect of intravitreal injections of Bevacizumab (IVB) alone or combined with triamcinolone (IVT) in the first injection for treatment of refractory diabetic macular oedema (DME). Sixty eyes of sixty patients with refractory DME were included. Half of the receive injections of IVB (1.25 mg/0.05 mL) or combined IVB and IVT (1.25 mg/0.05 mL and 2 mg/0.05 mL respectively). The primary outcome measure was change in central macular thickness (CMT). Secondary outcome measures were change in best-corrected logMAR visual acuity (BCVA) and incidence of potential adverse events. Central macular thickness was reduced significantly in both the IVB and IVB/IVT groups. At week 24, CMT change compared to the baseline was –95.7 mm (95% CI, –172.2 to –19.26) in the IVB group and –92.1 mm (95% CI, –154.4 to –29.7) in the IVB/IVT group. There was not a significant difference between the IVB and the IVB/IVT groups (p= 0.022). Improvement of BCVA was initiated at weeks 6 and 12 in the IVB/IVT and IVB groups respectively. In terms of BCVA change compared to the baseline at 24 weeks, the differences between the IVB and the IVB/IVT groups (p=0.006) were significant. Anterior Chamber reaction was noticed in six (20%) and six (20%) eyes respectively in the IVB and IVB/IVT groups the day after injection, and it resolved with no sequel. Elevation of IOP occurred in two eyes (6%) in the IVB/ IVT group. Intravitreal injections of Bevacizumab had a beneficial effect on refractory DME in terms of CMT reduction and BCVA improvement. Addition of triamcinolone in the injection seemed to induce earlier visual improvement; however, it did not show any significant additive effect later during follow-up.
Ključne riječi
bevacizumab; diabetic macular oedema
Hrčak ID:
51638
URI
Datum izdavanja:
20.4.2010.
Posjeta: 1.123 *