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Increased Bone Turnover Markers after Renal Transplantation

Antun Gršković ; Department of Urology, University Hospital of Rijeka, Rijeka, Croatia
Tanja Ćelić ; Department of Anatomy, School of Medicine, University of Rijeka, Rijeka, Croatia
Dora Fučkar ; Department of Pathology, School of Medicine, University of Rijeka, Rijeka, Croatia
Dean Markić ; Department of Urology, University Hospital of Rijeka, Rijeka, Croatia
Marin Trošelj ; Department of Urology, University Hospital of Rijeka, Rijeka, Croatia
Dragica Bobinac ; Department of Anatomy, School of Medicine, University of Rijeka, Rijeka, Croatia

Sažetak

Bone remodeling is a process that occurs continuously in a seemingly inactive tissue like bone. Because of decreased vitamin D synthesis, phosphorus retention and decreased calcium blood concentration, patients with chronic renal failure (CRF) develop secondary hyperparathyroidism1–5. Elevated PTH levels shifts balance between osteoblast and osteoclast activity in favor of osteoclast activity and, therefore, bone resorption. Bone metabolic disorder that affects patients with CRF is called renal osteodystrophy (ROD)1–5. We presume that renal transplantation reverses bone metabolism disorder and our goal was to establish whether osteoblast and osteoclast activity returns to the levels of healthy individuals.

Ključne riječi

chronic renal failure; renal transplantation; bone markers

Hrčak ID:

51647

URI

https://hrcak.srce.hr/51647

Datum izdavanja:

20.4.2010.

Posjeta: 1.143 *