Stručni rad
Prognostic Values of Morphological and Clinical Parameters in pT2 – pT3 Prostate Cancer in Elderly People
Romano Oguić
; Department of Urology, University Hospital »Rijeka«, Rijeka, Croatia
Eleonora Cini
; Department of Radiotherapy and Oncology,University Hospital »Rijeka«, Rijeka, Croatia
Gordana Đorđević
; Department of Pathology, School of Medicine, University Hospital, Rijeka, Croatia
Koviljka Matušan-Ilijaš
; Department of Pathology, School of Medicine, University Hospital, Rijeka, Croatia
Dean Markić
; Department of Urology, University Hospital »Rijeka«, Rijeka, Croatia
Marija Petković
; Department of Radiotherapy and Oncology,University Hospital »Rijeka«, Rijeka, Croatia
Sažetak
Prostate cancer is a disease of elderly men, hthe incidence of whic increases in an age dependent manner. This study presents the correlation of clinical and morphological parameters in locally confined (pT2) and locally advanced (pT3) prostate cancer. We analyzed a group of elderly men treated with radical prostatectomy in the period 1999–2008 in the University Hospital Rijeka. We found no statistical association between pT stage and age categories, preoperative prostate-specific antigen, digitorectal examination and biopsy Gleason score. There was a significant correlation of higher Gleason score in prostate specimens after radical prostatectomy and a higher frequency of a positive surgical margin in tumors with pT3 than in pT2 stage (p=0.003; p=0.011 respectively). Recurrence-free survival was shorter in patients with tumors with positive surgical margins as well as in patients with pT3 stage (p=0.030; p=0.001 respectively). We conclude that higher tumor grade and positive surgical margins are indicators of a worse prognosis in our patients.
Ključne riječi
prostatic neoplasms; prostatectomy; prostate-specific antigen
Hrčak ID:
51676
URI
Datum izdavanja:
20.4.2010.
Posjeta: 1.181 *