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Deletion/Deletion Genotype of Angiotensin-I Converting Enzyme Gene is not Associated with Coronary Artery Disease in Caucasians with Type 2 Diabetes

Ruda Zorc-Pleskovič
Nataša Teran
Aleš Pleskovič
Rifet Terzić
Aleksandra Milutinović


Puni tekst: engleski pdf 101 Kb

str. 149-152

preuzimanja: 463

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Sažetak

In this study we analyzed the contribution of genetic variability of the insertion/deletion (I/D) polymorphism of the angiotensin-I converting enzyme (ACE) gene to the predisposition for coronary artery disease (CAD) in a group of patients with type 2 diabetes. The I/D ACE gene polymorphism was tested in 366 Caucasians with type 2 diabetes: 148 cases with CAD and 218 subjects with no history of CAD. We failed to demonstrate that the ACE DD genotype was a risk factor for CAD in Caucasians with type 2 diabetes (OR 2.0, 95 % CI 0.9–4.7; p=0.1). In conclusion, we provide evidence that the ACE deletion/deletion genotype is not a risk factor for CAD in Caucasians with type 2 diabetes.

Ključne riječi

angiotensin-I converting enzyme; coronary artery disease; diabetes type 2

Hrčak ID:

4961

URI

https://hrcak.srce.hr/4961

Datum izdavanja:

15.6.2005.

Posjeta: 958 *