Skoči na glavni sadržaj

Izvorni znanstveni članak

Toxoplasma gondii infection in Philippines Rattus spp. confirmed through bioassay in Mus musculus

Cristina Cabanacan-Salibay
Florencia Garcia Claveria


Puni tekst: engleski pdf 346 Kb

str. 351-361

preuzimanja: 1.676

citiraj


Sažetak

The absence of any published work on T. gondii infection in rats in the Philippines has compelled us to embark
on this present study. Toxoplasma gondii infection was serologically ascertained in 55.5% of Rattus norvegicus
and Rattus rattus mindanensis caught in agricultural (AGR), commercial (COM) and residential (RES) sites at
Dasmariñas, Cavite. Infection accounted for 60.0% in R. norvegicus and 50.0% in R. rattus mindanensis, with
anti-T. gondii antibodies (Abs) titre ranging from 1:64 to 1:2048. Chronic infection (≥1:256 anti- T. gondii Abs)
was detected in 53 (61.0%) rats. There was an insignificant association between parasite infectivity, rat species
and collection sites. In mice, seropositivity was 65.0% (93/144), and tissue cysts were detected only among those
exposed to brain tissue of RES caught R. rattus mindanensis. Although mouse infection was clearly inoculum
dose related, the consistent higher infectivity of T. gondii parasite from AGR and COM relative to RES caught
Rattus spp. and other biological parameters, such as clinical manifestations, parasite encystations and mortality,
suggest intraspecific strain differences in T. gondii infecting the Rattus spp. populations. We are currently assessing
the severity of histopathology in seropositive mice exposed to brain tissue of chronically infected R. norvegicus
and R. rattus mindanensis across the three collection sites, and we hope to provide additional information that
would help clarify present findings and observations. The present study represents the first confirmed report of
T. gondii infection of rats in the country.

Ključne riječi

Toxoplasma gondii; Rattus spp.; Philippines; serology; experimental mice

Hrčak ID:

5144

URI

https://hrcak.srce.hr/5144

Datum izdavanja:

20.8.2006.

Posjeta: 2.619 *