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Gastric Pentadecapeptide BPC 157 Promotes Corneal Epithelial Defects Healing in Rats
Ratimir Lazić
Nikica Gabrić
Iva Dekaris
Damir Bosnar
Alenka Boban-Blagaić
Predrag Sikirić
Sažetak
We evaluated the role of human gastric pentadecapeptide BPC 157 in corneal epithelial defects healing in rats. 48 rats, in 4 groups (N=12). Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2pg/ml, 2ng/ml, 2μg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e., at 0, 8, 16, 24, 32, 40 h). Lesions were photographed before application or sacrifice (at 48 h). Defect area was analyzed using a special program. Through 48 hour period a steady recovery is noted in controls. Recovery was markedly accelerated in eyes on μg- or ng-topical regimen of BPC 157 (p<0.05). Of note, unlike control lesion present also after 48h, these lesions disappeared already following 40 h (μg) or 48 h (ng) post-injury. BPC 157 was shown to be effective in promoting corneal defects healing in rats. Results were dose dependent.
Ključne riječi
BPC 157; corneal epithelial defects; rats
Hrčak ID:
5198
URI
Datum izdavanja:
15.6.2005.
Posjeta: 1.575 *