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Arhiv za higijenu rada i toksikologiju, Vol. 54 No. 2, 2003.

Stručni rad

Lead Exposure in Toll-booth Operators

Azra Huršidić-Radulović
Janko Cvitković

Puni tekst: hrvatski pdf 379 Kb

str. 133-140

preuzimanja: 2.008

citiraj

Sažetak

Biomarkers of lead exposure (blood lead, BPb) and effect (erythrocyte protoporhyrin, EP, and activity of δ-aminolevulinic acid dehydratase, ALAD) were measured in 68 male toll-booth operators (aged 22-60 years) on the Zagreb-Karlovac motorway. Average values (arithmetic mean±standard deviation) were: 61.8±29.3 µg/L for BPb, 0.70±0.20 µmol/L erythrocytes for EP, and 50.6±9.8 U/L erythrocytes for ALAD. All were within the normal range determined for general population (BPb<150 µg/L, EP<1.62 µmol/L erythrocytes, and ALAD>35 U/L erythrocytes). A significant positive correlation was found between BPb and EP (r=0.367, P<0.01) and an inverse correlation between BPb and ALAD (r= -0.271, P<0.05) and for EP and ALAD (r=-0.381, P<0.01). Significant correlations were found between BPb or ALAD and smoking index (r=0.486, P<0.01, and r=-0.322, P<0.01, respectively), whereas BPb also significantly correlated with blood γ-glutamyl transferase (GGT) activity, which may indicate hepatotoxic effect of alcohol consumption (r=0.334, P<0.01). Among standard spirometric tests, BPb inversely correlated with FEV1 (r=-0.251, P<0.05) and Tiffenau index (r=-0.280, P<0.05), whereas ALAD positively correlated with FEF75-85 (r=0.261, P<0.05) and Tiffenau index (r=0.314, P<0.01). Among standard hematologic tests, BPb positively correlated with MCV (r=0.282, P<0.05), EP inversely correlated with erythrocyte count (r=-0.253, P<0.05), and ALAD positively correlated with MCHC (r=0.306, P<0.05) and inversely with MCV (r=-0.250, P<0.05). Although PbB values in these workers are within occupational exposure limits, they are higher than in corresponding occupations in developed countries. This may be explained by greater exposure to lead in ambient air, tobacco (through mainstream and sidestream smoking) and alcohol in this population.

Ključne riječi

δ-aminolevulinic acid dehydratase; blood lead; erythrocyte protoporphyrin; hematologic finding; spyrometric findings

Hrčak ID:

362

URI

https://hrcak.srce.hr/362

Datum izdavanja:

25.11.2003.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.876 *