Veterinarski arhiv, Vol. 80 No. 4, 2010.
Kratko priopćenje
Acute effects of doramectin on gastric acid secretion in anaesthetized rats - a short communication
Kennedy Erlwanger
; School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa
Terence Changara
; Preclinical Veterinary Department, Faculty of Veterinary Science, University of Zimbabwe, Mt Pleasant, Harare, Zimbabwe
Shepherd Sajeni
; Preclinical Veterinary Department, Faculty of Veterinary Science, University of Zimbabwe, Mt Pleasant, Harare, Zimbabwe
Darlington Masara
; Preclinical Veterinary Department, Faculty of Veterinary Science, University of Zimbabwe, Mt Pleasant, Harare, Zimbabwe
Sažetak
To investigate the acute effects of doramectin on basal and histamine-stimulated gastric secretion in anaesthetised rats, twenty adult female Sprague-Dawley rats were anaesthetised and their stomachs were cannulated and perfused with saline. Basal gastric acid secretion was collected from all rats. Doramectin (300 μg.kg-1, n = 5 and 600 μg.kg-1, n = 5) was then administered to ten rats intramuscularly, followed an hour later by histamine (100 μg.kg-1) subcutaneously. In another 10 rats the histamine was administered an hour before the doramectin. There was no significant change in gastric acid secretion compared to when doramectin alone was administered. Histamine, produced a significant increase (P<0.01) in gastric acid secretion. Doramectin neither potentiated nor decreased the effect of histamine on gastric acid secretion.
Ključne riječi
gastric acid; doramectin; rats; gamma amino butyric acid
Hrčak ID:
58467
URI
Datum izdavanja:
28.7.2010.
Posjeta: 1.224 *