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The Changes of Bone-Specific Alkaline Phosphatase (BsALP)Associated With Callus Formation and Rate of Bone Healing

Ante Muljačić ; University Hospital of Traumatology Zagreb, Draškovićeva 19, 10000 Zagreb, Croatia
Renata Poljak-Guberina ; School of Dental Medicine, University of Zagreb, Gundulićeva 5, 10000 Zagreb, Croatia
Josip Turčić ; University Hospital Center Zagreb, Kišpatićeva 12, 10000 Zagreb
Ognjen Živković ; Institute for Rehabilitation and Orthopaedic Aids of the Zagreb University Hospital Center, Božidarevićeva 11, 10000 Zagreb, Croatia
Marko Guberina ; School of Dental Medicine, University of Zagreb, Gundulićeva 5, 10000 Zagreb, Croatia
Boris Klaić ; Dental Polyclinic Zagreb, Perkovčeva 3, 10000 Zagreb, Croatia

Puni tekst: engleski pdf 1.084 Kb

str. 315-321

preuzimanja: 1.864



The aim of this study was to examine whether the volume of bone-specific alkaline phosphatase
(BsALP) as a biochemical parameter in the early posttraumatic phase may indicate the speed of fracture
healing. The evaluation of the bone healing process has been based on the patient's subjective statement
and radiographic findings. The activity of bone-specific alkaline phosphatase has been measured in the
sera of 41 patients who have been diagnosed with fractures of long bones. All the patients have been
surgically treated. The activity of BsALP was measured on each seventh day during a four-week period.
On the same patients the radiologically follow-up tests have been made during a period of seven months.
Our research has shown that the increase of alkaline phosphatase correlates with an increase of BsALP
levels. The volume of callus correlates with the level of ALP and BsALP. The result leads us to a conclusion
that by monitoring the changes of biochemical parameters: alkaline phosphatase and bone-specific
alcaline phosphatase, we can be able to predict the dynamics of the bone healing.

Ključne riječi

Prognostic Significance, BsALP, Long Bone Fractures

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