Stručni rad

Cold haemagglutinin disease in two French bulldog pups-a case report

Marko Hohšteter orcid.org/0000-0001-8844-2660 ; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Croatia
Branka Artuković ; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Croatia
Ana Beck ; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Croatia
Andrea Gudan Kurilj ; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Croatia
Ivan Conrado Šoštarić-Zuckermann ; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Croatia
Marijana Ćorić ; Clinical Health Center Zagreb, Department of Clinical Pathology, Zagreb, Croatia
Goran Bačić ; Clinic for Reproduction and Obstetric, Faculty of Veterinary Medicine, University of Zagreb, Croatia
Branka Šeol ; Department for Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary Medicine, University of Zagreb, Croatia
Zrinka Štritof ; Department for Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary Medicine, University of Zagreb, Croatia
Željko Grabarević ; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Croatia

Sažetak

Cold haemagglutinin disease (CHD) was diagnosed in two newborn French bulldog pups. Necropsy revealed cyanosis and necrosis, formation of crusts on all anatomic extremities and amputation of the lower parts of the hind limbs. Histologically, cutaneous necrosis was found on the limbs of both animals, with blood vessel thrombosis, hemorrhages and predominantly neutrophilic infiltration, which affected the periosteum of the metatarsal bones. The surfaces of the necrotic areas were covered with thick crusts with Gram positive bacterial colonies. In the spleen and liver erythrophagocytosis was present. Lung congestion, alveolar edema and thrombosis of pulmonary artery branches, cerebral and chorioidal vessels were present. Immunohistochemicaly, lymphocytes and plasma cells in necrotic tissue were positive for IgM. Bacteriological examination of swabs from necrotic areas revealed the presence of Staphylococcus aureus. The diagnosis of CHD was based on macroscopic and histopathologic findings, which were identical to those described in literature and were supported by immunohistochemical reactivity to IgM.

Ključne riječi

cold haemagglutinin disease; immune-mediated haemolytic anaemia; pathology; pup

Hrčak ID:

62773

URI

https://hrcak.srce.hr/62773

Datum izdavanja:

16.12.2010.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.752 *