Pregledni rad

SYSTEMIC SCLEROSIS – PATHOGENESIS, CLINICAL MANIFESTATIONS AND TREATMENT

MISLAV RADIĆ
DUŠANKA MARTINOVIĆ KALITERNA
DAMIR FABIJANIĆ
JOSIPA RADIĆ

Sažetak

Diffuse systemic sclerosis (SSc) is a chronic disease of unknown cause characterized by diffuse fibrosis and vascular abnormalities in the skin and internal organs. Pathogenesis of SSc involves immunologic mechanisms, vascular damage and activation of fibroblasts. SSc varies in severity and progression; most patients eventually develop visceral complications, which are the usual causes of death. No drug significantly influences the natural history of SSc overall, but various drugs are of value in treating specific symptoms or organ systems. This review discusses pathogenesis, clinical manifestations and possible treatment of SSc.

Ključne riječi

Scleroderma, systemic – immunology, diagnosis, therapy; Fibroblasts – immunology

Hrčak ID:

63580

URI

https://hrcak.srce.hr/63580

Datum izdavanja:

30.6.2010.

Podaci na drugim jezicima: hrvatski

Posjeta: 3.459 *