Izvorni znanstveni članak

Relationship between adiponectin and testosterone in patients with type 2 diabetes

Jie Bai ; Department of Endocrinology, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Shandong, PR China
Yu Liu ; Department of Endocrinology, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Shandong, PR China
Gui-Fen Niu ; Department of Endocrinology, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Shandong, PR China
Li-Xin Bai ; Department of Endocrinology, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Shandong, PR China
Xiao-Yan Xu ; Department of Pharmacy, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Shandong, PR China
Guang-Zhen Zhang ; Department of Pharmacy, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Shandong, PR China
Le-Xin Wang ; School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia

Sažetak

Introduction: This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes.
Materials and methods: Serum level of adiponectin and testosterone were prospectively measured in 65 patients with type 2 diabetes and in 20 healthy subjects. Testosterone was determined by the radio-immunoassay, whereas adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA).
Results: The average serum testosterone did not differ between the diabetes and the control group, but the average adiponectin in the diabetes group was lower (14.6 (14.2-15.0) vs. 24.3 (24.05-24.55) ng/mL, P = 0.001). In the diabetes group, the serum adiponectin level in patients with renal dysfunction (22.3 (21.5-23.1) ng/mL) was higher than in patients with no complications (12.1 (11.45-12.75) ng/mL) and than in patients with coronary artery disease (11.2 (10.25-12.15) ng/mL) (P = 0.009). Univariate correlation analysis showed an inverse weak correlation between adiponectin and testosterone concentrations in male diabetic patients (r = -0.27, P = 0.009). There was no significant correlation between adiponectin and testosterone in female patients (r = -0.05, P = 0.167).
Conclusions: We conclude that patients with type 2 diabetes have lower serum adiponectin concen-tration than healthy individuals, and that there is a weak inverse correlation between adiponectin and testosterone serum concentrations in male diabetics.

Ključne riječi

type 2 diabetes; adiponectin; testosterone; renal function; coronary artery disease

Hrčak ID:

64502

URI

https://hrcak.srce.hr/64502

Datum izdavanja:

15.2.2011.

Posjeta: 1.837 *