Infektološki glasnik, Vol. 31 No. 1, 2011.
Pregledni rad
Immunoprophylaxis of recurrent urinary tract infections with lyophilized bacterial lysate of Escherichiae coli
Višnja Škerk
; Klinika za infektivne bolesti "Dr. Fran Mihaljević"
Sažetak
Immunostimulating drugs have been used for over 40 years in trying to prevent recurrent urinary tract infections (UTI) in women. Vaccines for oral, intramuscular injection, and vaginal administration are in the process of testing, consisting of various combinations of extracted immunostimulating fractions of heathinactivated uropathogenic bacteria. The bacterial extract OM-89 (OM Laboratories, Geneve, Switzerland) has been used in clinical practice. It contains extracted immunostimulating fractions derived from 18 E. coli strains that are most frequently responsible for community acquired UTIs. In five prospective randomized clinical trials and two meta-analyses with more than 1 000 examinees OM-89 proved as effective and safe drug that significantly reduces the incidence of recurrent UTI episodes, incidence of bacteriuria and leukocyturia and antimicrobial consumption. Preventive effectiveness of OM-89 lasts for at least three months after cessation. The advantage of OM-89 is that it can be used over a longer period without concern for development of bacterial antimicrobial resistance and other side effects that accompany long-term antimicrobial therapy.
Ključne riječi
urinary tract infections; E.coli; immunoprophylaxis; immunotherapy; OM-89
Hrčak ID:
66767
URI
Datum izdavanja:
31.3.2011.
Posjeta: 2.563 *