Review article

Metastasis – recent scientific insights and challenging new therapeutic approaches

MARTINA DEŽELJIN ; Laboratory for Molecular Oncology, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10002 Zagreb, Croatia
MAJA HERAK BOSNAR orcid.org/0000-0002-8448-4713 ; Laboratory for Molecular Oncology, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10002 Zagreb, Croatia

Abstract

Majority of cancer patients never die from the original disease – primary tumor – but from the metastasis that disseminate throughout the body. Although they disseminate in millions only few of them succeeded in their journey and achieve their main goal – form a distant metastatic colony which is able to thrive in an inhospitable environment of an unrelated tissue. This review will summarize in brief some of the recent advances in cancer invasion and metastasis investigations and possibilities in using these findings for the benefit of cancer patients.

Keywords

metastasis; epithelial-mesenchymal transition; cancer stem cells; metastasis suppressor genes; dormancy

Hrčak ID:

101205

URI

https://hrcak.srce.hr/101205

Publication date:

30.9.2012.

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