Professional paper
Application of the Amniotic Membrane Extract (AMX) for the Persistent Epithelial Defect (PED) of the Cornea
Rajko Kordić
; University of Zagreb, Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Smiljka Popović Suić
; University of Zagreb, Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Sonja Jandroković
; University of Zagreb, Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Miro Kalauz
; University of Zagreb, Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Tomislav Kuzman
; University of Zagreb, Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Ivan Škegro
; University of Zagreb, Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Tomislav Jukić
; University of Zagreb, Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Abstract
A lot of pathological conditions could provoke damaging of the innervations of the cornea and lead to persistent epithelial defect (PED). AMX is lyophilized preparation of amniotic membrane (AM), which contains biological components and efficacy of AM for treatment of the corneal surface defects. In processing all the substances essential for biological effects of AM are preserved (growth factors, neutrophins, interleukins, receptors, fibronectins and different types of collagen). A patient can apply AMX as eye drops by himself in his home, thus avoiding surgical procedure. We presented two patients with PED; we treated them with eye drops of AMX, 2 drops every hour during day time. There was observed healing effect by reducing epithelial defect. Almost after a second day of application, and after 1-2 week period PED that persisted for weeks healed completely.
Keywords
Amniotic membrane extract; persistent epithelial defect; neurotrophic keratopathy
Hrčak ID:
102880
URI
Publication date:
22.4.2013.
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