Original scientific paper
Clinical, Hormonal and Metabolic Characteristics of Polycystic Ovary Syndrome among Obese and Nonobese Women in the Croatian Population
Dinka Pavičić Baldani
; University of Zagreb, School of Medicine, University Hospital Center Zagreb, Clinic for Women’s Diseases, Department of
Lana Škrgatić
; University of Zagreb, School of Medicine, University Hospital Center Zagreb, Clinic for Women’s Diseases, Department of
Marina Šprem Goldštajn
; University of Zagreb, School of Medicine, University Hospital Center Zagreb, Clinic for Women’s Diseases, Department of
Hrvoje Vrčić
; University of Zagreb, School of Medicine, University Hospital Center Zagreb, Clinic for Women’s Diseases, Department of
Tomislav Čanić
; University of Zagreb, School of Medicine, University Hospital Center Zagreb, Clinic for Women’s Diseases, Department of
Mihajlo Strelec
; University of Zagreb, School of Medicine, University Hospital Center Zagreb, Clinic for Women’s Diseases, Department of
Abstract
Obesity has a deteriorating impact on women with PCOS, although prevalence and the impact of specific traits of PCOS remain inconstant in different populations. Therefore, the aim of this study was to explore the differences in clinical, hormonal and metabolic features between obese and nonobese Croatian women diagnosed as having PCOS according to Rotterdam consensus criteria. The study included 74 obese and 208 nonobese women with PCOS. Clinical, biochemical and metabolic variables were compared among those PCOS subgroups. Obese subjects with PCOS had a higher risk of developing oligo-amenorrhea (OR 3.7; 95% CI, 1.1–12.5) and lower risk for developing hirsutism and acne (OR 0.2; 95% CI, 0.1–0.3 and OR 0.8; 95% CI 0.5–1.4, respectively). Obese PCOS subjects also had a higher risk of developing hyperandrogenemia (OR 2.5; CI 95% 0.9–6.7), insulin resistance (OR 4.5; CI 95%, 2.6–7.9), hypercholesterolemia (OR 5.0, CI 95% 2.5–10.2), hypertriglyceridemia (OR 5.2; 95% CI, 2.9–9.2) as well as elevated serum CRP levels (OR 4.1; 95% CI 1.4–12.2) compared to nonobese PCOS women. In conclusion, nonobese Croatian women with PCOS are more inclined to cosmetic problems associated with PCOS then metabolic ones. This is the first study to report the impact of obesity
on acne and irregular menses as a study outcome. Obesity deteriorates menstrual regularity, insulin sensitivity and lipid profile in Croatian women with PCOS; therefore one of the fundamental treatment strategies of PCOS should be obesity prevention.
Keywords
PCOS; obesity; hyperandrogenism; insulin resistance; dyslipidemia
Hrčak ID:
104484
URI
Publication date:
1.7.2013.
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