Original scientific paper

Levofloxacin disposition and urinary excretion in febrile cross bred calves.

Vinod K. Dumka ; Department of Pharmacology and Toxicology College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India
Anil K. Srivastava ; Department of Pharmacology and Toxicology College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India

Abstract

Disposition and urinary excretion of levofloxacin following a single intravenous administration of 4 mg/kg body mass were investigated in six febrile crossbred calves. The drug levels in plasma and urine were estimated by microbiological assay. Levofloxacin was rapidly distributed from the blood to the tissue compartment, as evidenced by the high values of the distribution coefficient (9.93 ± 0.73 h -1). The high AUC (11.5 ± 0.95 µg/mL/h) indicated good antibacterial activity of levofloxacin in calves. The elimination half-life, volume of distribution and total body clearance were 2.22 ± 0.07 h, 1.18 ± 0.15 L/kg and 0.36 ± 0.03 L/kg/h, respectively. About 37.7 per cent of the administered dose of levofloxacin was eliminated in urine within 24 h. An appropriate intravenous dosage regimen for levofloxacin would be 5.0 mg/kg, repeated at 12 h intervals for the treatment of bacterial infections, manifested with fever in calves.

Keywords

calves; disposition; excretion; febrile; levofloxacin

Hrčak ID:

105357

URI

https://hrcak.srce.hr/105357

Publication date:

8.7.2013.

Article data in other languages: croatian

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