Original scientific paper

https://doi.org/10.5562/cca2151

A New Complex of Palladium(II) With 2-Furoic Hydrazide: Synthesis, Characterization, Theoretical Calculations and Biological Studies

Gustavo Duarte de Souza ; Instituto de Química, Universidade Federal de Uberlândia, Campus Santa Mônica, 38400-902, Uberlândia - MG, Brazil
Mônica Aparecida Rodrigues ; Instituto de Química, Universidade Federal de Uberlândia, Campus Santa Mônica, 38400-902, Uberlândia - MG, Brazil
Priscila Pereira Silva ; Departamento de Química, Universidade Federal de Minas Gerais, Campus Pampulha, 31.270-901, Belo Horizonte - MG, Brazil
Elene Cristina Pereira-Maia ; Departamento de Química, Universidade Federal de Minas Gerais, Campus Pampulha, 31.270-901, Belo Horizonte - MG, Brazil
Françoise Vasconcelos Botelho ; Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia, Campus Umuarama, 38400-902, Uberlândia - MG, Brazil
Tatiana Amabile de Campos ; Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia, Campus Umuarama, 38400-902, Uberlândia - MG, Brazil; Departamento de Biologia Celular, Universidade de Brasília, Campus Darcy Ribeiro, 70910-900, Distrito Federal- DF, Brazil
Eduardo de Faria Franca ; Instituto de Química, Universidade Federal de Uberlândia, Campus Santa Mônica, 38400-902, Uberlândia - MG, Brazil
Katia Júlia de Almeida ; Instituto de Química, Universidade Federal de Uberlândia, Campus Santa Mônica, 38400-902, Uberlândia - MG, Brazil
Wendell Guerra ; Instituto de Química, Universidade Federal de Uberlândia, Campus Santa Mônica, 38400-902, Uberlândia - MG, Brazil

Abstract

A new complex of palladium was isolated with 2-furoic hydrazide (FH) and characterized by
spectroscopic methods. The results show that the ligand is coordinated to palladium by the basic nitrogen
of NH2 group and has a general structure of type cis-[Pd(FH)2Cl2]. The structure of palladium(II) complex
was optimized and theoretical data show good agreement with the experimental results. The cytotoxic
activity was evaluated in a chronic myelogenous leukemia cell line, which revealed that the compound is
less active than cisplatin or carboplatin. At 300 g mL−1, the complex presented antimicrobial activity
more efficient than ampicillin, chloranfenicol and kanamicyn. (doi: 10.5562/cca2151)

Keywords

palladium complexes; hydrazides; hydrazones; DFT studies; antibacterial activity

Hrčak ID:

105586

URI

https://hrcak.srce.hr/105586

Publication date:

1.7.2013.

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