Acta clinica Croatica, Vol. 51. No. 2., 2012.
Other
False-Positive Methadone Urine Drug Screen in a Patient Treated with Quetiapine
Davor Lasić
orcid.org/0000-0001-7571-0291
Boran Uglešić
Marija Žuljan-Cvitanović
Daniela Šupe-Domić
Lovro Uglešić
Abstract
We present a case of T.M. admitted to University Department of Psychiatry, Split University Hospital Center, in Croatia, because of the acute psychotic reaction (F23.9). The patient’s urine tested positive for methadone without a history of methadone ingestion. Urine drug screen was performed with the COBAS Integra Methadone II test kit (kinetic interaction of microparticles in solution /KIMS/ methodology) by Roche. Drugs that have been shown to cross-react with methadone feature a tricyclic structure with a sulfur and nitrogen atom in the middle ring, which is common for both quetiapine and methadone. Therefore, it is plausible that this structural similarity between quetiapine and methadone could underlie the cross-reactivity on methadone drug screen. Besides quetiapine, a number of routinely prescribed medications have been associated with triggering false-positive urine drug screen results. Verification of the test results with a different screening test or additional analytical tests should be performed to avoid adverse consequences for the patients.
Keywords
Quetiapine; Methadone; False-positive urine drug screen
Hrčak ID:
106652
URI
Publication date:
1.7.2012.
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