Original scientific paper

https://doi.org/10.2478/10004-1254-64-2013-2328

Cytogenetic Damage in Turkish Coke Oven Workers Exposed to Polycyclic Aromatic Hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 Gene Polymorphisms

Ahmet Oguz Ada ; Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandogan, Turkey
Canan Demiroglu ; Department of Toxicology, Faculty of Pharmacy, Gazi University, Etiler, Turkey
Meltem Yilmazer ; Department of Toxicology, Faculty of Pharmacy, Gazi University, Etiler, Turkey
Halit Sinan Suzen ; Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandogan, Turkey
Ali Eba Demirbag ; Gastrointestinal Surgery Department, Yuksek Ihtisas Hospital, Sihhiye, Ankara, Turkey
Sibel Efe ; Eregli Iron and Steel Works Co., Karadeniz Eregli, Turkey
Yilmaz Alemdar ; Eregli Iron and Steel Works Co., Karadeniz Eregli, Turkey
Mumtaz Iscan ; Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandogan, Turkey
Sema Burgaz ; Department of Toxicology, Faculty of Pharmacy, Gazi University, Etiler, Turkey

Abstract

The aim of this study was to determine the frequencies of chromosomal aberrations (CA) and cytochalasinblocked micronuclei (CBMN) in peripheral blood lymphocytes from Turkish coke oven workers and the influence of CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms on these biomarkers. Cytogenetic analysis showed that occupational exposure significantly increased the CA and CBMN frequencies. Gene polymorphisms, on the other hand, did not affect CA or CBMN in either exposed or control subjects. However, due to the limited sample size, our findings need to be verified in future studies with a larger sample.

Keywords

chromosomal aberrations; biomarkers; micronuclei; occupational exposure

Hrčak ID:

107533

URI

https://hrcak.srce.hr/107533

Publication date:

20.9.2013.

Article data in other languages: croatian

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