Review article

https://doi.org/10.2478/10004-1254-64-2013-2371

Antineoplastic DNA-Binding Compounds: Intercalating and Minor Groove Binding Drugs

Katarina Mišković orcid.org/0000-0001-5048-7628 ; J. J. Strossmayer University, Faculty of Medicine, Department of Medicinal Chemistry, Biochemistry and Clinical Chemistry, Osijek, Croatia
Maro Bujak ; Ruđer Bošković Institute, Department of Molecular Medicine, Laboratory for Systems Biomedicine, Zagreb, Croatia
Mirela Baus Lončar ; Biomedicine, Zagreb, Croatia
Ljubica Glavaš-Obrovac ; J. J. Strossmayer University, Faculty of Medicine, Department of Medicinal Chemistry, Biochemistry and Clinical Chemistry, Osijek, Croatia

Abstract

DNA intercalating and minor groove binding compounds are new weapons in the battle against malignant diseases. These antineoplastic agents target the DNA molecule and interfere with the cell cycle leading to rapidly proliferating cell death. They are mainly derivates of a naturally occurring organic compound derived from a microorganism or plant. Intercalators usually act as topoisomerase I and/or II poisons, while the mechanisms of DNA minor groove binders are a combination of several steps including topoisomerase poisoning. This paper gives an overview of some of the developed DNA intercalating and minor groove binding compounds, as well as an explanation of their chemical structures, origins, and application in chemotherapy.

Keywords

chemotherapy; DNA intercalator; DNA minor groove binder; organic compounds derivatives

Hrčak ID:

111788

URI

https://hrcak.srce.hr/111788

Publication date:

6.12.2013.

Article data in other languages: croatian

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