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Croatian Medical Journal, Vol. 54 No. 5, 2013.

Original scientific paper

https://doi.org/10.3325/cmj.2013.54.453

Somatic comorbidity, metabolic syndrome, cardiovascular risk, and CRP in patients with recurrent depressive disorders

Radmila Topić ; Department of Psychiatry, University of Zagreb School of Medicine, University Clinical Centre Zagreb, Zagreb, Croatia
Davor Miličić ; Department of Cardiology, University of Zagreb School of Medicine, University Clinical Centre Zagreb, Zagreb, Croatia
Zoran Štimac ; Department of Psychiatry, University of Zagreb School of Medicine, University Clinical Centre Zagreb, Zagreb, Croatia
Mladen Lončar ; Department of Psychiatry, University of Zagreb School of Medicine, University Clinical Centre Zagreb, Zagreb, Croatia
Vedran Velagić ; Department of Cardiology, University of Zagreb School of Medicine, University Clinical Centre Zagreb, Zagreb, Croatia
Darko Marčinko ; Department of Psychiatry, University of Zagreb School of Medicine, University Clinical Centre Zagreb, Zagreb, Croatia
Miro Jakovljević ; Department of Psychiatry, University of Zagreb School of Medicine, University Clinical Centre Zagreb, Zagreb, Croatia

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Abstract

Aim To investigate the association between depression,
metabolic syndrome (MBS), somatic, particularly cardiovascular
comorbidity, and low-grade chronic inflammation assessed
using C-reactive protein (CRP).
Methods This cross-sectional study included 76 patients
with recurrent depressive disorder (RDD) and 72 non-depressed
medical staff controls from the Department of Psychiatry,
University Hospital Center Zagreb between January
2011 and June 2012.
Results Seventy-five percent of patients had somatic comorbidity.
The most common comorbid conditions were
cardiovascular disorders (46.1%), locomotor system diseases
(35.5%), carcinoma (15.8%), thyroid diseases (9.2%), and
diabetes (9.2%). MTB was more common in RDD patients
(31.6%) than in controls (23.6%), but the difference was
not significant. Elevated CRP was found to be significantly
more frequent in patients with recurrent depressive disorders
(RDD) (35.5%; χ2 test, P = 0.001, Cramer V = 0.29) than
in controls (12.5%) and was associated with lowered highdensity
lipoprotein and overweight/obesity.
Conclusion We found some intriguing links between
stress, depression, metabolic syndrome, and low grade
inflammation, which may be relevant for the prevalence
of somatic comorbidity in patients with RDD, but further
studies are needed to confirm our results.

Keywords

Hrčak ID:

117010

URI

https://hrcak.srce.hr/117010

Publication date:

15.10.2013.

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