Acta Pharmaceutica, Vol. 57 No. 3, 2007.
Short communication, Note
https://doi.org/10.2478/v10007-007-0028-2
Preparation and characterization of etoricoxib -cyclodextrin complexes prepared by the kneading method
HARESH M. PATEL
BHANUBHAI N. SUHAGIA
SHAILESH A. SHAH
ISHWAR SINH RATHOD
VIJAY K. PARMAR
Abstract
The binary system of etoricoxib with β-cyclodextrin (β-CD) was prepared by the kneading method. Drug-cyclodextrin interactions in solution were investigated by the phase solubility analysis. Differential scanning calorimetry, infrared spectroscopy, powder X-ray diffractometry and microscopic study were used to characterize the solid state of all binary systems, whereas their dissolution properties were evaluated according to the USP XXIII paddle method. The results indicate partial interaction of the drug with β-CD in the physical mixture and complete interaction in the kneaded complex. The dissolution of etoricoxib was notably increased as compared to pure drug as well as its physical mixture. The complex showed more than 75% drug released in 30 min.
Keywords
etoricoxib; cyclodextrin; complexation; kneading method
Hrčak ID:
12065
URI
Publication date:
1.9.2007.
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